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Article

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency.

Drug design, development and therapy - 1 Jan 2015

Yan Meng, Zhang Kaiping, Shi Yanhui, Feng Lifang, Lv Lin, Li Baoxin

Abstract excerpt

Berberine (BBR), an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in clinics. It has been reported that BBR can block human ether-a-go-go-related gene (hERG) potassium channel and inhibit its membrane expression. The hERG channel plays crucial role in cardiac repolarization and is the target of diverse proarrhythmic drugs....

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Identifiers

PMID: 26543354
DOI: 10.2147/DDDT.S91561
PMCID: PMC4622489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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