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Article

Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2006

Kiesecker Claudia, Alter Markus, Kathöfer Sven, Zitron Edgar, Scholz Eberhard P, Thomas Dierk, Kreuzer Jörg, Katus Hugo A, Bauer Alexander, Karle Christoph A

Abstract excerpt

Maprotiline is an antidepressant compound with an atypical tetracyclic structure that is widely used in elderly patients due to its favourable side-effect profile. However, there have been reports of proarrhythmia associated with maprotiline and in vitro studies of its electrophysiological properties have been lacking. Therefore, we characterised the effects of maprotiline on cardiac hERG channels. hERG channels...

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PMID: 16736158
DOI: 10.1007/s00210-006-0068-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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