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Article

hERG potassium channels and cardiac arrhythmia.

Nature - 23 Mar 2006

Sanguinetti Michael C, Tristani-Firouzi Martin

Abstract excerpt

hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs. This side effect is a common reason for drug failure in preclinical safety trials. Insights...

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Source

Identifiers

PMID: 16554806
DOI: 10.1038/nature04710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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