Article
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.
PloS one - 1 Jan 2012
El Harchi Aziza, Melgari Dario, Zhang Yi Hong, Zhang Henggui, Hancox Jules C
Abstract excerpt
BACKGROUND: The familial Short QT Syndrome (SQTS) is associated with an increased risk of cardiac arrhythmia and sudden death. Gain-of-function mutations in the hERG K(+) channel protein have been linked to variant 1 of the SQTS. A hERG channel pore (T618I) mutation has recently been identified in families with heritable SQTS. This study aimed to determine effects of the T618I-hERG mutation on (i) hERG current...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.