Article
Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.
Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2005
Scholz Eberhard P, Zitron Edgar, Kiesecker Claudia, Lück Sonja, Thomas Dierk, Kathöfer Sven, Kreye Volker A W, Katus Hugo A, Kiehn Johann, Schoels Wolfgang, Karle Christoph A
Abstract excerpt
Flavonoids are naturally occurring food ingredients that have been associated with reduced cardiovascular mortality in epidemiological studies. In a previous study, we demonstrated for the first time that flavonoids are inhibitors of cardiac human ether-à-go-go-related gene (HERG) channels. Furthermore, we observed that grapefruit juice induced mild QTc prolongation in healthy subjects. HERG blockade by...
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