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Article

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval.

EBioMedicine - 1 Mar 2023

Hiniesto-Iñigo Irene, Castro-Gonzalez Laura M, Corradi Valentina, Skarsfeldt Mark A, Yazdi Samira, Lundholm Siri, Nikesjö Johan, Noskov Sergei Yu, Bentzen Bo Hjorth, Tieleman D Peter, Liin Sara I

Abstract excerpt

BACKGROUND: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes. Therefore, there is a need to identify factors influencing disease severity to move towards an individualized clinical management of LQTS. One possible factor influencing the disease phenotype is the endocannabinoid system, which has...

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PMID: 36796231
DOI: 10.1016/j.ebiom.2023.104459
PMCID: PMC9958262

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