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Article

Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.

Journal of cardiovascular pharmacology - 1 Dec 2008

Kim Young Jin, Hong Hee Kyung, Lee Hui Sun, Moh Sang Hyun, Park Jong Cook, Jo Su Hyun, Choe Han

Abstract excerpt

Papaverine, a vasodilator used as a therapeutic agent for a range of diseases, has been reported to increase the risk of occasional serious ventricular arrhythmias. To examine the mechanism for this effect, we herein tested the effects of papaverine on human ether-a-go-go (HERG) K channels expressed in HEK293 cells and Xenopus oocytes. Our results revealed that papaverine dose-dependently decreased the tail...

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Source

Identifiers

PMID: 19034039
DOI: 10.1097/FJC.0b013e31818e65c2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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