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Article

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.

Neurogenetics - 1 Jun 2004

Blomqvist Mia E-L, Silburn Peter A, Buchanan Daniel D, Andreasen Niels, Blennow Kaj, Pedersen Nancy L, Brookes Anthony J, Mellick George D, Prince Jonathan A

Abstract excerpt

We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme ( IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15088150
DOI: 10.1007/s10048-004-0173-4

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.PMID 15088150Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.Semantic proximity Read ↗

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population.Semantic proximity Read ↗

Age at onset in two common neurodegenerative diseases is genetically controlled.Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.Semantic proximity Read ↗

Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.Semantic proximity Read ↗

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