Article
Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2007
Ueno Takamasa, Idegami Yuka, Motozono Chihiro, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
The mutational escape of HIV-1 from established CTL responses is becoming evident. However, it is not yet clear whether antigenic variations of HIV-1 may have an additional effect on the differential antiviral effectiveness of HIV-specific CTLs. Herein, we characterized HIV-specific CTL responses toward Pol, Env, and Nef optimal epitopes presented by HLA-B*35 during a chronic phase of HIV-1 infection. We found...
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