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Article

Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.

Neuron - 3 Aug 2006

McEwen Jason M, Madison Jon M, Dybbs Michael, Kaplan Joshua M

Abstract excerpt

Priming of synaptic vesicles (SVs) is essential for synaptic transmission. UNC-13 proteins are required for priming. Current models propose that UNC-13 stabilizes the open conformation of Syntaxin, in which the SNARE helix is available for interactions with Synaptobrevin and SNAP-25. Here we show that Tomosyn inhibits SV priming. Tomosyn contains a SNARE motif, which forms an inhibitory SNARE complex with...

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Identifiers

PMID: 16880125
DOI: 10.1016/j.neuron.2006.06.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.PMID 16880125Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

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Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

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A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

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