Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.

PLoS biology - 1 Jul 2006

Gracheva Elena O, Burdina Anna O, Holgado Andrea M, Berthelot-Grosjean Martine, Ackley Brian D, Hadwiger Gayla, Nonet Michael L, Weimer Robby M, Richmond Janet E

Abstract excerpt

Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis of synaptic vesicles in vivo, we analyzed C. elegans tom-1 mutants. Our electrophysiological analysis indicates that evoked postsynaptic responses at tom-1 mutant synapses are prolonged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Electrophysiology

Share to Neuromuscular Junction

Share to Protein Isoforms

Share to Sequence Alignment

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 16895441
DOI: 10.1371/journal.pbio.0040261
PMCID: PMC1514790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.PMID 16895441Read ↗

Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

Endoplasmic reticulum proteins MCTP-1 and ESYT-2 support presynaptic function during sustained activity in Caenorhabditis elegans.Semantic proximity Read ↗

In vivo analysis of conserved C. elegans tomosyn domains.Semantic proximity Read ↗

Cornichons control ER export of AMPA receptors to regulate synaptic excitability.Semantic proximity Read ↗

Complexin has opposite effects on two modes of synaptic vesicle fusion.Semantic proximity Read ↗

Regulation of Mechanosensor PIEZO Channel Trafficking in <i>C. elegans</i> GermlineSemantic proximity Read ↗

Differential expression and function of synaptotagmin 1 isoforms in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.