Article
Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
Nature structural & molecular biology - 1 Jul 2015
Yang Xiaoyu, Wang Shen, Sheng Yi, Zhang Mingshu, Zou Wenjuan, Wu Lijie, Kang Lijun, Rizo Josep, Zhang Rongguang, Xu Tao, Ma Cong
Abstract excerpt
UNC-13-Munc13s have a central function in synaptic-vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to mediate the transition from the Munc18-1-closed syntaxin-1 complex to the SNARE complex in vitro. The crystal structure of the rat Munc13-1 MUN domain now reveals an elongated, arch-shaped architecture formed by α-helical bundles,...
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