UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.

doi:10.1523/JNEUROSCI.0338-17.2017

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Article

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Sept 2017

Park Seungmee, Bin Na-Ryum, Yu Bin, Wong Raymond, Sitarska Ewa, Sugita Kyoko, Ma Ke, Xu Junjie, Tien Chi-Wei, Algouneh Arash, Turlova Ekaterina, Wang Siyan, Siriya Pranay, Shahid Waleed, Kalia Lorraine, Feng Zhong-Ping, Monnier Philippe P, Sun Hong-Shuo, Zhen Mei, Gao Shangbang, Rizo Josep, Sugita Shuzo

Abstract excerpt

Munc18-1/UNC-18 is believed to prime SNARE-mediated membrane fusion, yet the underlying mechanisms remain enigmatic. Here, we examine how potential gain-of-function mutations of Munc18-1/UNC-18 affect locomotory behavior and synaptic transmission, and how Munc18-1-mediated priming is related to Munc13-1/UNC-13 and Tomosyn/TOM-1, positive and negative SNARE regulators, respectively. We show that a...

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PMID: 28821673
DOI: 10.1523/JNEUROSCI.0338-17.2017
PMCID: PMC5588468

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UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.PMID 28821673Read ↗

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.Semantic proximity Read ↗

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

Defects in synaptic vesicle docking in unc-18 mutants.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

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