Article

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutants

2020-01-11

Abstract excerpt

<h4>Summary</h4> Assembly of SNARE complexes that mediate neurotransmitter release requires opening of a ‘closed’ conformation of UNC-64/syntaxin. Rescue of unc-13/Munc13 phenotypes by overexpressed open UNC-64/syntaxin suggested a specific function of UNC-13/Munc13 in opening UNC-64/ syntaxin. Here, we revisit the effects of open unc-64 /syntaxin by generating knockin (KI) worms. The KI animals exhibited enhan...

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Literature Corpus work: f78dcaaa-d51d-5359-bc9b-e5e8c1f283fe
DOI: 10.1101/2020.01.10.901835

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