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Article

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.

Nature communications - 2 Nov 2020

Tien Chi-Wei, Yu Bin, Huang Mengjia, Stepien Karolina P, Sugita Kyoko, Xie Xiaoyu, Han Liping, Monnier Philippe P, Zhen Mei, Rizo Josep, Gao Shangbang, Sugita Shuzo

Abstract excerpt

Assembly of SNARE complexes that mediate neurotransmitter release requires opening of a 'closed' conformation of UNC-64/syntaxin. Rescue of unc-13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin suggested a specific function of UNC-13/Munc13 in opening UNC-64/ syntaxin. Here, we revisit the effects of open unc-64/syntaxin by generating knockin (KI) worms. The KI animals exhibit enhanced spontaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33139696
DOI: 10.1038/s41467-020-19178-x
PMCID: PMC7606450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.PMID 33139696Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Semantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses.Semantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.Semantic proximity Read ↗

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

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