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Article

UNC-13 interaction with syntaxin is required for synaptic transmission.

Current biology : CB - 20 Dec 2005

Madison Jon M, Nurrish Stephen, Kaplan Joshua M

Abstract excerpt

Neurotransmitter secretion at synapses is controlled by several processes-morphological docking of vesicles at release sites, priming of docked vesicles to make them fusion competent, and calcium-dependent fusion of vesicles with the plasma membrane . In worms, flies, and mice, mutants lacking UNC-13 have defects in vesicle priming . Current models propose that UNC-13 primes vesicles by stabilizing Syntaxin's...

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Source

Identifiers

PMID: 16271476
DOI: 10.1016/j.cub.2005.10.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

UNC-13 interaction with syntaxin is required for synaptic transmission.PMID 16271476Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.Semantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Drosophila UNC-13 is essential for synaptic transmission.Semantic proximity Read ↗

The M domain in UNC-13 regulates the probability of neurotransmitter release.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants.Semantic proximity Read ↗

Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.Semantic proximity Read ↗

Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.Semantic proximity Read ↗

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