Selective, genetically induced increase in synaptic vesicle priming.

Abstract excerpt

Synaptic vesicle (SV) release probability (Pv) is determined by two probabilistic factors: the probability of release sites being occupied by fusion-competent, well-primed SVs and their fusion probability (Pfusion). While recent studies emphasize SV priming as a key mechanism underlying functional synaptic diversity, disentangling priming from fusion is notoriously challenging. Here we developed a mouse genetic...

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