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Article

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

Neuron - 25 Mar 2004

Bai Jihong, Wang Chih-Tien, Richards David A, Jackson Meyer B, Chapman Edwin R

Abstract excerpt

Exocytosis involves the formation of a fusion pore that connects the lumen of secretory vesicles with the extracellular space. Exocytosis from neurons and neuroendocrine cells is tightly regulated by intracellular [Ca2+] and occurs rapidly, but the molecular events that mediate the opening and subsequent dilation of fusion pores remain to be determined. A putative Ca2+ sensor for release, synaptotagmin I (syt),...

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Source

Identifiers

PMID: 15046725
DOI: 10.1016/s0896-6273(04)00117-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.PMID 15046725Read ↗

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Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.Semantic proximity Read ↗

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Semantic proximity Read ↗

The C2 domains of synaptotagmin--partners in exocytosis.Semantic proximity Read ↗

Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.Semantic proximity Read ↗

Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.Semantic proximity Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.Semantic proximity Read ↗

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