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Article

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021

Padmanarayana Murugesh, Liu Haowen, Michelassi Francesco, Li Lei, Betensky Daniel, Dominguez Matthew J, Sutton R Bryan, Hu Zhitao, Dittman Jeremy S

Abstract excerpt

Neurotransmitter release during synaptic transmission comprises a tightly orchestrated sequence of molecular events, and Munc13-1 is a cornerstone of the fusion machinery. A forward genetic screen for defects in neurotransmitter release in Caenorhabditis elegans identified a mutation in the Munc13-1 ortholog UNC-13 that eliminated its unique and deeply conserved C-terminal module (referred to as HC2M) containing...

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Identifiers

PMID: 33836576
DOI: 10.1073/pnas.2016276118
PMCID: PMC7980281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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