Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.

doi:10.1128/AAC.00112-06

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Article

Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Aug 2006

Hazbón Manzour Hernando, Brimacombe Michael, Bobadilla del Valle Miriam, Cavatore Magali, Guerrero Marta Inírida, Varma-Basil Mandira, Billman-Jacobe Helen, Lavender Caroline, Fyfe Janet, García-García Lourdes, León Clara Inés, Bose Mridula, Chaves Fernando, Murray Megan, Eisenach Kathleen D, Sifuentes-Osornio José, Cave M Donald, Ponce de León Alfredo, Alland David

Abstract excerpt

The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. However, small sample sizes and related potential biases in sample selection have precluded the development of statistically valid and significant population genetic analyses of clinical isoniazid resistance. We present the first...

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PMID: 16870753
DOI: 10.1128/AAC.00112-06
PMCID: PMC1538650

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