Prevalence of mutations in genes associated with isoniazid resistance in Mycobacterium tuberculosis isolates from re-treated smear-positive pulmonary tuberculosis patients: A meta-analysis.

doi:10.1016/j.jgar.2018.02.009

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Article

Prevalence of mutations in genes associated with isoniazid resistance in Mycobacterium tuberculosis isolates from re-treated smear-positive pulmonary tuberculosis patients: A meta-analysis.

Journal of global antimicrobial resistance - 1 Sept 2018

Alagappan Chitra, Sunil Shivekar Smita, Brammacharry Usharani, Cuppusamy Kapalamurthy Vidya Raj, Sakkaravarthy Anbazhagi, Subashkumar Rathinasamy, Muthaiah Muthuraj

Abstract excerpt

OBJECTIVES: The prevalence of isoniazid (INH) monoresistance is high in India. In this study, molecular epidemiological characteristics associated with INH resistance mutations in Mycobacterium tuberculosis in codon katG315 and in the promoter region of the inhA gene were investigated. METHODS: Sputum specimens of smear-positive tuberculosis (TB) patients were subjected to GenoType MTBDRplus assay to identify...

Topics

Age Factors
Bacterial Proteins
Catalase
Female
Genotyping Techniques
Humans
India
Isoniazid
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Oxidoreductases

Prevalence

Promoter Regions, Genetic

Sputum

Tuberculosis, Pulmonary

Source

Open in PubMed

Identifiers

PMID: 29604431
DOI: 10.1016/j.jgar.2018.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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