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Article

Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Apr 2003

Ramaswamy Srinivas V, Reich Robert, Dou Shu-Jun, Jasperse Linda, Pan Xi, Wanger Audrey, Quitugua Teresa, Graviss Edward A

Abstract excerpt

Isoniazid (INH) is a central component of drug regimens used worldwide to treat tuberculosis. Previous studies have identified resistance-associated mutations in katG, inhA, kasA, ndh, and the oxyR-ahpC intergenic region. DNA microarray-based experiments have shown that INH induces several genes in Mycobacterium tuberculosis that encode proteins physiologically relevant to the drug's mode of action. To gain...

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Identifiers

PMID: 12654653
DOI: 10.1128/AAC.47.4.1241-1250.2003
PMCID: PMC152487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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