Article
Genome sequencing of Mycobacterium tuberculosis clinical isolates revealed isoniazid resistance mechanisms undetected by conventional molecular methods.
International journal of antimicrobial agents - 1 Aug 2020
Laurent Sacha, Zakham Fathiah, Bertelli Claire, Merz Laurent, Nicod Laurent, Mazza-Stalder Jesica, Greub Gilbert, Jaton Katia, Opota Onya
Abstract excerpt
A combination of targeted molecular methods and phenotypic drug-susceptibility testing is the most widely used approach to detect drug resistance in Mycobacterium tuberculosis isolates. We report the delay in the introduction of an efficient anti-tuberculous drug regimen because of a M. tuberculosis strain displaying a high level of resistance to isoniazid, in the absence of the common mutations associated with...
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