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Article

Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA

9 Oct 2006

Abstract excerpt

Drug-resistant tuberculosis poses a significant problem for treatment. The mechanisms of resistance to the front-line drug isoniazid (INH) are complex and can be mediated by katG, inhA and other unknown genes. To identify the percentage of INH-resistant strains with no katG or inhA mutation, this study characterized a panel of 28 clinical isolates of Mycobacterium tuberculosis and five mutants derived from H37Rv...

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PMID: 17030912
DOI: 10.1099/jmm.0.46718-0

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