Mutation profiling for detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

doi:10.1093/jac/dkv253

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Article

Mutation profiling for detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

The Journal of antimicrobial chemotherapy - 1 Dec 2015

Jagielski Tomasz, Bakuła Zofia, Roeske Katarzyna, Kamiński Michał, Napiórkowska Agnieszka, Augustynowicz-Kopeć Ewa, Zwolska Zofia, Bielecki Jacek

Abstract excerpt

OBJECTIVES: Progress in the detection of drug-resistant TB has been underpinned by the development and implementation of new, reliable and rapid diagnostic tools. These rely mostly on the detection of specific mutations conferring resistance to anti-TB drugs. The aim of this study was to search for mutations associated with isoniazid resistance among Mycobacterium tuberculosis clinical isolates. METHODS: A...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Antitubercular Agents
Drug Resistance, Bacterial
Female
Genes, Bacterial
Genotype
Humans
Isoniazid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Mycobacterium tuberculosis

Polymerase Chain Reaction

Regulatory Sequences, Nucleic Acid

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 26311839
DOI: 10.1093/jac/dkv253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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