Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates.

doi:10.1128/spectrum.02496-25

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Article

Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates.

Microbiology spectrum - 7 Apr 2026

Wu Xiaomeng, Zheng Huiwen, Chen Yiyi, Zhao Bing, Li Feina, Xia Hui, Xiao Jing, Qi Hui, Jiao Weiwei, Mi Kaixia, Ou Xichao, Zhao Yanlin, Sun Lin

Abstract excerpt

To characterize the mutation profile of the ahpC gene in isoniazid resistance (INHr) Mycobacterium tuberculosis (MTB) isolates and to evaluate the correlation between specific mutations and resistance levels, a total of 1,337 INHr MTB isolates were collected through the Chinese Drug Resistance Surveillance Program (2013-2020). The minimum inhibitory concentrations (MICs) for INH, rifampicin (RIF), and ethionamide...

Topics

Mycobacterium tuberculosis
Isoniazid
Antitubercular Agents
Bacterial Proteins
Humans
Microbial Sensitivity Tests
Mutation
Tuberculosis, Multidrug-Resistant
Oxidoreductases
Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rifampin

Whole Genome Sequencing

Prevalence

China

Catalase

Ethionamide

Peroxiredoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 41856489
DOI: 10.1128/spectrum.02496-25
PMCID: PMC13055390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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