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Article

Detecting novel genetic variants associated with isoniazid-resistant Mycobacterium tuberculosis.

PloS one - 1 Jan 2014

Shekar Sandhya, Yeo Zhen Xuan, Wong Joshua C L, Chan Maurice K L, Ong Danny C T, Tongyoo Pumipat, Wong Sin-Yew, Lee Ann S G

Abstract excerpt

BACKGROUND: Isoniazid (INH) is a highly effective antibiotic central for the treatment of Mycobacterium tuberculosis (MTB). INH-resistant MTB clinical isolates are frequently mutated in the katG gene and the inhA promoter region, but 10 to 37% of INH-resistant clinical isolates have no detectable alterations in currently known gene targets associated with INH-resistance. We aimed to identify novel genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25025225
DOI: 10.1371/journal.pone.0102383
PMCID: PMC4099304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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