Article
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Nature cell biology - 1 Aug 2006
Ziv Yael, Bielopolski Dana, Galanty Yaron, Lukas Claudia, Taya Yoichi, Schultz David C, Lukas Jiri, Bekker-Jensen Simon, Bartek Jiri, Shiloh Yosef
Abstract excerpt
The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is mobilized by the nuclear protein kinase ATM, which modulates this process by phosphorylating key players in these pathways. A long-standing question in this field is whether DSB formation affects chromatin condensation. Here, we show that DSB...
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