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Article

Early events in the mammalian response to DNA double-strand breaks

13 May 2008

Abstract excerpt

Physical and chemical agents that induce DNA double-strand breaks (DSBs) are among the most potent mutagens. The mammalian cell response to DSB comprises a highly co-ordinated, yet complex network of proteins that have been categorized as sensors, signal transducers, mediators and effectors of damage and repair. While this provides an accessible classification system, review of the literature indicates that many...

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PMID: 18644834
DOI: 10.1093/mutage/gen039

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