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Article

Chromatin dynamics during repair of chromosomal DNA double-strand breaks

1 Dec 2009

Abstract excerpt

The integrity of a eukaryotic genome is often challenged by DNA double-strand breaks (DSBs). Even a single, unrepaired DSB can be a lethal event, or such unrepaired damage can result in chromosomal instability and loss of genetic information. Furthermore, defects in the pathways that respond to and repair DSBs can lead to the onset of several human pathologic disorders with pleiotropic clinical features,...

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PMID: 20495614
DOI: 10.2217/epi.09.22

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