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Article

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.

Science signaling - 7 Dec 2010

Bensimon Ariel, Schmidt Alexander, Ziv Yael, Elkon Ran, Wang Shih-Ya, Chen David J, Aebersold Ruedi, Shiloh Yosef

Abstract excerpt

The double-strand break (DSB) is a cytotoxic DNA lesion caused by oxygen radicals, ionizing radiation, and radiomimetic chemicals. Cells cope with DNA damage by activating the DNA damage response (DDR), which leads either to damage repair and cellular survival or to programmed cell death. The main transducer of the DSB response is the nuclear protein kinase ataxia telangiectasia mutated (ATM). We applied...

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Identifiers

PMID: 21139141
DOI: 10.1126/scisignal.2001034

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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