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Article

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.

Journal of applied genetics - 1 Jan 2008

Czornak Kamila, Chughtai Sanaullah, Chrzanowska Krystyna H

Abstract excerpt

Genomes are subject to a number of exogenous or endogenous DNA-damaging agents that cause DNA double-strand breaks (DSBs). These critical DNA lesions can result in cell death or a wide variety of genetic alterations, including deletions, translocations, loss of heterozygosity, chromosome loss, or chromosome fusions, which enhance genome instability and can trigger carcinogenesis. The cells have developed an...

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Source

Identifiers

PMID: 19029686
DOI: 10.1007/BF03195638

Genes

ATM
ATR
MRE11
NBN
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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