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DNA Damage Responses: Mechanisms and Roles in Human Disease

1 Apr 2008

Abstract excerpt

Significant progress has been made in recent years in elucidating the molecular controls of cellular responses to DNA damage in mammalian cells. Much of our understanding of the mechanisms involved in cellular DNA damage response pathways has come from studies of human cancer susceptibility syndromes that are altered in DNA damage responses. Ataxia-telangiectasia mutated (ATM), the gene mutated in the disorder...

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PMID: 18403632
DOI: 10.1158/1541-7786.mcr-08-0020

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