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Article

Nucleolar responses to DNA double-strand breaks

28 Nov 2015

Abstract excerpt

Maintenance of cellular homeostasis is key to prevent transformation and disease. The cellular response to DNA double-strand breaks, primarily orchestrated by the ATM/ATR kinases is one of many mechanisms that serve to uphold genome stability and homeostasis. Upon detection of double-strand breaks (DSBs), several signaling cascades are activated to halt cell cycle progression and initiate repair. Furthermore, the...

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PMID: 26615196
DOI: 10.1093/nar/gkv1312

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