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Article

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

31 Jul 2019

Abstract excerpt

The DNA damage response (DDR) encompasses the cellular response to DNA double-stranded breaks (DSBs), and includes recognition of the DSB, recruitment of numerous factors to the DNA damage site, initiation of signaling cascades, chromatin remodeling, cell-cycle checkpoint activation, and repair of the DSB. Key drivers of the DDR are multiple members of the phosphatidylinositol 3-kinase-related kinase family,...

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PMID: 31396623
DOI: 10.1093/nar/gkz694

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