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Article

The impact of heterochromatin on DSB repair.

Biochemical Society transactions - 1 Jun 2009

Goodarzi Aaron A, Noon Angela T, Jeggo Penny A

Abstract excerpt

DNA NHEJ (non-homologous end-joining) is the major DNA DSB (double-strand break) repair pathway in mammalian cells. Although NHEJ-defective cell lines show marked DSB-repair defects, cells defective in ATM (ataxia telangiectasia mutated) repair most DSBs normally. Thus NHEJ functions independentl...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Chromosomal Proteins, Non-Histone
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19442252
DOI: 10.1042/BST0370569

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19442252-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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