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Article

Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation.

Drug metabolism and pharmacokinetics - 1 Jun 2006

Markova Svetlana, Nakamura Tsutomu, Sakaeda Toshiyuki, Makimoto Hiroo, Uchiyama Hitoshi, Okamura Noboru, Okumura Katsuhiko

Abstract excerpt

Recent advances in pharmacogenomics have suggested the association of clinical outcome of glucocorticoid-based anti-inflammatory therapy with a single nucleotide polymorphism at position 3435 in exon 26 (C3435T) of the MDR1 gene. In the present study, the effects of the MDR1 C3435T genotype on the time-dependent profiles of gene expression and function of MDR1/P-glycoprotein were evaluated in peripheral blood...

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PMID: 16858122
DOI: 10.2133/dmpk.21.194

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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