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Article

IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation.

Biological & pharmaceutical bulletin - 1 Aug 2007

Markova Svetlana, Nakamura Tsutomu, Makimoto Hiroo, Ichijima Tomoki, Yamamori Motohiro, Kuwahara Akiko, Iwaki Koichi, Nishiguchi Kohshi, Okamura Noboru, Okumura Katsuhiko, Sakaeda Toshiyuki

Abstract excerpt

Glucocorticoids such as prednisolone are used for their anti-inflammatory properties. But there is evidence to suggest that under certain conditions, glucocorticoids have pro-inflammatory effects, for example, enhancement of IL-1beta production. To date, it has been reported that IL-1beta production intensity was associated with single nucleotide polymorphisms at positions -1470, -511, and -31 in the promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17666808
DOI: 10.1248/bpb.30.1481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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