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MDR1 gene polymorphisms are associated with glucocorticoid-induced avascular necrosis of the femoral head in a Chinese population.

Genetic testing and molecular biomarkers - 1 Mar 2014

Xue Yun, Zhao Zhan-Qin, Hong Dun, Zhang Hong-Jun, Chen Hai-Xiao, Fan Shun-Wu

Abstract excerpt

P-glycoprotein (P-gp) is present in various tissue cells, required for the pumping of lipophilic drugs (including glucocorticoids) out of cells. We hypothesized that polymorphisms in the P-gp encoding gene (multidrug-resistant transporter-1 [MDR1]) are related to individual differences in glucocorticoid sensitivity and the development of glucocorticoid-induced avascular necrosis of the femoral head (GANFH). In...

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Identifiers

PMID: 24387690
DOI: 10.1089/gtmb.2013.0374
PMCID: PMC3948596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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