Article
Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil rheumatoid arthritis.
European journal of clinical pharmacology - 1 Aug 2015
Muralidharan Niveditha, Antony Paul T, Jain Vikramraj K, Mariaselvam Christina Mary, Negi Vir Singh
Abstract excerpt
PURPOSE: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily targeting the synovial joints causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA, and approximately 10-30% of the patients fail to attain remission because of inefficacy of the drug or due to development of adverse events. Multidrug resistance 1 (MDR1) gene...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- Adult
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Female
- Genotype
- Humans
- India
- Male
- Methotrexate
- Phenotype
- Polymorphism, Genetic
- Severity of Illness Index
- White People