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Article

Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment.

Rheumatology international - 1 Apr 2017

Cuppen Bart V J, Pardali Katerina, Kraan Maarten C, Marijnissen Anne C A, Yrlid Linda, Olsson Marita, Bijlsma Johannes W J, Lafeber Floris P J G, Fritsch-Stork Ruth D E

Abstract excerpt

A substantial proportion of rheumatoid arthritis (RA)-patients experience an insufficient response to glucocorticoids, an important therapeutic agent in RA. The multidrug-resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is an efflux pump that actively transports substrates, such as glucocorticoids, out of the cell. We investigated if the variation in response might be explained by single-nucleotide...

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Identifiers

PMID: 28132103
DOI: 10.1007/s00296-017-3653-1
PMCID: PMC5357283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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