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Article

MMP-8 genotypes influence the inflammatory response in human endotoxemia.

Inflammation - 1 Apr 2014

Rella Judith M, Jilma Bernd, Fabry Astrid, Kaynar A Murat, Mayr Florian B

Abstract excerpt

Clinical studies have reported associations between MMP-8 genotypes and clinical outcomes without exploring underlying mechanisms. This study aims to understand the influence of the rs1940475 SNP on downstream chemokine and cytokine response in human endotoxemia. Rs1940475 was genotyped in 44 healthy Caucasian males, who were challenged with an intravenous bolus of 2 ng/kg lipopolysaccharide (LPS). Plasma levels...

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Identifiers

PMID: 24170307
DOI: 10.1007/s10753-013-9758-0
PMCID: PMC7101851

Genes

MIP
TNF

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