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Article

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

Gastroenterology - 1 Jan 2003

Schwab Matthias, Schaeffeler Elke, Marx Claudia, Fromm Martin F, Kaskas Bernd, Metzler Joerg, Stange Eduard, Herfarth Hans, Schoelmerich Juergen, Gregor Michael, Walker Siegfried, Cascorbi Ingolf, Roots Ivar, Brinkmann Ulrich, Zanger Ulrich M, Eichelbaum Michel

Abstract excerpt

BACKGROUND & AIMS: The human multidrug resistance 1 (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics. The finding that mdr1a knockout mice develop a form of colitis that is similar to ulcerative colitis, which can be prevented by antibiotics, indicates a barrier function for P-glycoprotein against the invasion of bacteria or...

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Source

Identifiers

PMID: 12512026
DOI: 10.1053/gast.2003.50010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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