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Article

Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4

27 Jan 2020

Abstract excerpt

Glucocorticoids are potent endogenous anti-inflammatory molecules, and their cognate receptor, glucocorticoid receptor (GR), is expressed in nearly all immune cells. Macrophages are heterogeneous immune cells having a central role in both tissue homeostasis and inflammation and also play a role in the pathogenesis of some inflammatory diseases. Paradoxically, glucocorticoids have only a limited efficacy in...

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PMID: 31988243
DOI: 10.1074/jbc.ra119.010894

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