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Article

Functional flexibility of Bacillus stearothermophilus formamidopyrimidine DNA-glycosylase.

DNA repair - 13 Aug 2006

Amara Patricia, Serre Laurence

Abstract excerpt

The formamidopyrimidine-DNA glycosylase (Fpg) recognizes and eliminates efficiently 8-oxoguanine, an abundant mutagenic DNA lesion. The X-ray structure of the inactive E3Q mutant of Fpg from Bacillus stearothermophilus, complexed to an 8-oxoG-containing DNA, revealed a small peptide (called the alphaF-beta10 loop) involved in the recognition of the lesion via an interaction with the protonated N(7) atom. This...

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PMID: 16857432
DOI: 10.1016/j.dnarep.2006.05.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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