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Article

Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA.

The Journal of biological chemistry - 31 May 2002

Gilboa Rotem, Zharkov Dmitry O, Golan Gali, Fernandes Andrea S, Gerchman Sue Ellen, Matz Eileen, Kycia Jadwiga H, Grollman Arthur P, Shoham Gil

Abstract excerpt

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. The Schiff base intermediate formed during this reaction between Escherichia coli Fpg and DNA was trapped by reduction with sodium borohydride, and the structure of the resulting covalently cross-linked complex was determined at a 2.1-A resolution. Fpg is a bilobal protein with a wide, positively...

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Identifiers

PMID: 11912217
DOI: 10.1074/jbc.M202058200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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