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Article

DNA damage processing by human 8-oxoguanine-DNA glycosylase mutants with the occluded active site.

The Journal of biological chemistry - 4 Oct 2013

Lukina Maria V, Popov Alexander V, Koval Vladimir V, Vorobjev Yuri N, Fedorova Olga S, Zharkov Dmitry O

Abstract excerpt

8-Oxoguanine-DNA glycosylase (OGG1) removes premutagenic lesion 8-oxoguanine (8-oxo-G) from DNA and then nicks the nascent abasic (apurinic/apyrimidinic) site by β-elimination. Although the structure of OGG1 bound to damaged DNA is known, the dynamic aspects of 8-oxo-G recognition are not well understood. To comprehend the mechanisms of substrate recognition and processing, we have constructed OGG1 mutants with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23955443
DOI: 10.1074/jbc.M113.487322
PMCID: PMC3789988

Genes

OGG1

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