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Article

Molecular dynamics approach to identification of new OGG1 cancer-associated somatic variants with impaired activity.

The Journal of biological chemistry - 1 Jan 2000

Popov Aleksandr V, Endutkin Anton V, Yatsenko Darya D, Yudkina Anna V, Barmatov Alexander E, Makasheva Kristina A, Raspopova Darya Yu, Diatlova Evgeniia A, Zharkov Dmitry O

Abstract excerpt

DNA of living cells is always exposed to damaging factors. To counteract the consequences of DNA lesions, cells have evolved several DNA repair systems, among which base excision repair is one of the most important systems. Many currently used antitumor drugs act by damaging DNA, and DNA repair often interferes with chemotherapy and radiotherapy in cancer cells. Tumors are usually extremely genetically...

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Identifiers

PMID: 33361155
DOI: 10.1074/jbc.RA120.014455
PMCID: PMC7948927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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