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Article

A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase.

Nucleic acids research - 29 Jan 2016

Li Haoquan, Endutkin Anton V, Bergonzo Christina, Campbell Arthur J, de los Santos Carlos, Grollman Arthur, Zharkov Dmitry O, Simmerling Carlos

Abstract excerpt

In contrast to proteins recognizing small-molecule ligands, DNA-dependent enzymes cannot rely solely on interactions in the substrate-binding centre to achieve their exquisite specificity. It is widely believed that substrate recognition by such enzymes involves a series of conformational changes in the enzyme-DNA complex with sequential gates favoring cognate DNA and rejecting nonsubstrates. However, direct...

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Identifiers

PMID: 26553802
DOI: 10.1093/nar/gkv1092
PMCID: PMC4737139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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