Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of 8-oxoguanine on DNA structure and deformability.

The journal of physical chemistry. B - 3 Oct 2013

Dršata Tomáš, Kara Mahmut, Zacharias Martin, Lankaš Filip

Abstract excerpt

8-Oxoguanine (oxoG) is an abundant product of oxidative DNA damage. It is removed by repair glycosylases, but exactly how the enzymes recognize oxoG in the large surplus of undamaged bases is not fully understood. The lesion may induce changes in the properties of naked DNA that facilitate the recognition. In this work, we assess the effect of oxoG on DNA structure and mechanical deformability. We performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Bacterial Proteins
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to Guanine

Share to Mechanical Phenomena

Share to Molecular Dynamics Simulation

Share to Nucleic Acid Conformation

Source

Identifiers

PMID: 24028561
DOI: 10.1021/jp407562t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of 8-oxoguanine on DNA structure and deformability.PMID 24028561Read ↗

Global deformation facilitates flipping of damaged 8-oxo-guanine and guanine in DNA.Semantic proximity Read ↗

A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase.Semantic proximity Read ↗

Molecular mechanisms associated with clustered lesion-induced impairment of 8-oxoG recognition by the human glycosylase OGG1Semantic proximity Read ↗

Distinctive Formation of a DNA-Protein Cross-Link during the Repair of DNA Oxidative Damage: Insights into Human Disease from MD Simulations and QM/MM Calculations.Semantic proximity Read ↗

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.Semantic proximity Read ↗

Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition.Semantic proximity Read ↗

Structural and biochemical analysis of DNA helix invasion by the bacterial 8-oxoguanine DNA glycosylase MutM.Semantic proximity Read ↗

Analysis of an anomalous mutant of MutM DNA glycosylase leads to new insights into the catalytic mechanism.Semantic proximity Read ↗

Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic.Semantic proximity Read ↗

Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases.Semantic proximity Read ↗

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.Semantic proximity Read ↗

Mapping the sequence logic of DNA repair enzyme binding reveals mechanistic principles and evolutionary linksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.